ChloroquineV1, Main, Exploration, bibRecord, 003084

Biochemical effects of luxabendazole on Trichinella spiralis

Identifieur interne : 003084 ( Main/Exploration ); précédent : 003083; suivant : 003085

Biochemical effects of luxabendazole on Trichinella spiralis

Auteurs : A. Criado-Fornelio [Espagne] ; C. De Armas-Serra [Espagne] ; A. Jimenez-Gonzalez [Espagne] ; N. Casado-Escribano [Espagne] ; F. Rodriguez-Caabeiro [Espagne]

Source :

Parasitology Research [ 0932-0113 ] ; 1990-06-01.

RBID : ISTEX:6F48F03578909DDA6D3584EDB6527F85A3DE1374

English descriptors

Teeft :
- Anthelmintic, Ascaris suum, Assay, Biochemical effects, Colchicine, Colchicine binding, Free glucose, Fumarate reductase activity, Glucose, Glucose uptake, Glycogen, Glycogen contents, Glycogen levels, Glycogen reserves, Larva, Luxabendazole, Microtubule, Microtubule protein, Mitochondrial fraction, Other benzimidazoles, Parasitol, Present study, Previous work, Protein contents, Reductase, Spiralis, Standard pepsin digestion, Succinate dehydrogenase, Trichinella spiralis, Tubulin, Vivo treatment.

Abstract

Abstract: Biochemical changes produced by luxabendazole in muscle-stageTrichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9×10−7 M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin.

Url:

https://api.istex.fr/ark:/67375/1BB-G7PQP02F-0/fulltext.pdf

DOI: 10.1007/BF00931057

Affiliations:

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to stream Istex, to step Curation: 002849
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Le document en format XML

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<author><name sortKey="Jimenez Gonzalez, A" sort="Jimenez Gonzalez, A" uniqKey="Jimenez Gonzalez A" first="A." last="Jimenez-Gonzalez">A. Jimenez-Gonzalez</name>
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<term>Fumarate reductase activity</term>
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<term>Glucose uptake</term>
<term>Glycogen</term>
<term>Glycogen contents</term>
<term>Glycogen levels</term>
<term>Glycogen reserves</term>
<term>Larva</term>
<term>Luxabendazole</term>
<term>Microtubule</term>
<term>Microtubule protein</term>
<term>Mitochondrial fraction</term>
<term>Other benzimidazoles</term>
<term>Parasitol</term>
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<term>Previous work</term>
<term>Protein contents</term>
<term>Reductase</term>
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<front><div type="abstract" xml:lang="en">Abstract: Biochemical changes produced by luxabendazole in muscle-stageTrichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9×10−7 M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin.</div>
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Biochemical effects of luxabendazole on Trichinella spiralis

Biochemical effects of luxabendazole on Trichinella spiralis

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri